I have an Anet A8 printer for about 4 months, set up pretty well (or so I thought) and printing a number of models pretty well. I made a large 3" x 6" box with a sliding lid yesterday and when it was done there was a gap on one side when the lid was slid on. I checked the parts and it turns out they are not square - which means the X and Y axes are not square to each other.
I'm wondering how to adjust this - I'm thinking that extending the distance between the back of the frame and the front by adjusting the threaded rods that separate them to a wider distance on the side where the angle is obtuse. Obviously one of the first things I'll check is that the distance between the front and back is the same (I can't imagine why I never checked that before, come to think of it).
Does this sound like a sound plan?
I recently went to the same issue on my CoreXY printer (culprit was uneven belt tension in the 2 belts), but you have a Prusa style printer like my first Anet A8 printer.
If you just found out (because you are printing large models now) but always had this issue it could be frame related. You should check your printer and try to fix the geometry that is causing this. If this is impossible you could fix this by changing the firmware (see below). If large prints used to be accurate, but are now skewed, you could be facing stretched belts. Replacing them will fix the issue.
Skewness compensation in Marlin: When X-Y are skew (or any other plane like X-Z or Y-Z) you can fix that through the firmware software in Marlin Firmware. Please go into the Configuration.h file and look at the instructions; please search for "Bed Skew Compensation".
Basically you are required to print a giant square and measure the diagonals, these should be the same, but apparently are not in your case.