I mean, I really should be glad when they ask me this question. But inevitably, different people will ask me the same question many different times (over many different interviews), understandably so, and response fatigue does start to set in. I just wonder how other people can manage to be so patient when I ask them the same exact question (that they've probably answered hundreds of times by now).
I guess one of the things that has always driven me (despite an initially subpar educational background) was that I was always extremely averse to any form of redundant stimuli or repetitiveness. This helped carry me from a crappy middle school into UChicago/Brown. But I do need to get used to it a bit more as my role changes.
I have been in the same situation - having to explain the same thing over and over again, usually in interviews and such... The way I dealt with it was to explain it in a fresh way every time. So, on one occasion I may focus on the "fun" part of that work, while another time I may focus on the discovery part of it, while yet another time I may focus on the teamwork that was needed... The interviewer may give me a clue (body language, vernacular, etc) as to what type of answer may work best for their media/platform, so I tune into that. If it is a younger audience, I will try to make the answer more fun and attractive, while if it is for a serious, older audience, my answer will focus on serious matters more. Say a project I worked on was both famous and earned a lot of money - in a show for teens I may talk about fun part of it and perhaps someone famous I met, while in the other, serious show I may throw in figures and profits and such and perhaps even the whole industry a bit, to make it interesting for their audience. This also gives a benefit to the listener who may have seen/heard/read more than one of my interviews and would not be bored by repetition (although some repetition is to be expected).