On my Reprap-like 3D printer, I routed all the wires to a spot near the base; for the motors, endstops, thermistors, etc, I plugged them all into a DB25 breakout board, and that's working great.
For my Extruder (12v), and my heat bed (16v), I'm using a 4-pin molex connector -- like we used to use for old hard drives and such, and it's working, but it gets a bit hot, and my print bed is having trouble reaching temperatures that it didn't have trouble with before. -- None of the wiring gets hot at any other point, and none of the other connectors get hot. -- The only thing that gets hot is this one molex connector.
I believe the heat is caused by passing too much current through that molex connector. -- I'm curious to know what other connectors might be better suited to this task. Can you recommend something that's worked well for you, or others?
I prefer not to double or triple up this connector if it can be avoided, so that I can just have one physical connector to disconnect there, and so that I don't end up mixing them up. -- also, being able to easily disconnect it is important (it's hard to work on the reprap if I can't spin it around or turn it over, etc., that's why I'm using connectors for everything).
You might be able to use one of the connectors (Deans Ultra, EC3, XT-60/30, Bullet) that are normally used for RC models. They're made for very high currents. The XT60 connectors depicted below are rated for 60A continuous (well above what you'd need for any heated bed); their smaller XT30 cousins are good for 30A but less commonly available.
For your extruder you wouldn't need anything quite as drastic as an XT60, even a simple JST connector would suffice (though if you are going to source XT60/30's for your heated bed anyway, you might use them here as well).