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- More images, and less text. A poster is a highly visual, two dimensional medium, and you should use the real estate as such. Since poster viewers will be skimming it while you explain something to another viewer, it's best to have lots of pictures so they can get a gist of the ideas.
- PPT slides are the poor man's way of making slides on the quick. But they're not ideal. Again, it's best to use the entire real estate as a continuous medium, rather than as a set of tiles (unless you can do some creative flowing with the set of tiles).
- Having said all of that, readers still like some sense of progression through the poster, so it helps to have visual cues (arrows, arcs, etc) that help the reader understand the order in which to read things.